In the present work, there was a positive correlation between level of TNF-α, the inflammatory reaction of hepatic tissue and degree of fibrosis induced by CCl4 toxicity, these positive correlation was discussed by yang et al.[64] who reported that TNF-α induced HSC survival, hepatocytes necrosis, and inflammatory reaction all resulted in hepatic fibrosis. The gene discussed is TNF; the disease is Hepatic fibrosis.