PPP1R3B and type 2 diabetes mellitus: In contrast, our investigation of a large number of deeply phenotyped patients with T2D and control individuals indicates that the presence of rare deleterious PPP1R3B variants increases the risk of developing T2D, associates with an elevated level of HbA1C, a decreased waist-hip ratio, an elevated birth weight and among patients with T2D, of whom the majority of carriers were men, increased concentrations of plasma LDL-cholesterol (S1 Fig).