INS and diabetes mellitus: The genomic region including PPP1R3B shows linkage to both T2D and monogenic diabetes [6,7], and genome-wide association studies (GWASs) have investigated the association of common variants in PPP1R3B with glucose metabolism and found significant associations with both T2D [8] and glycaemic traits such as association with decreased levels of fasting plasma glucose [9,10], increased levels of fasting serum insulin [11] in addition to increased serum levels of high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol [9].