PPP1R3B and type 2 diabetes mellitus: The association between rare PPP1R3B missense variants and measures of glucose metabolism were examined among 4,569 glucose tolerant individuals of whom 12 were carriers, 1,157 pre-diabetic participants of whom six were carriers (Table 2) and 2,930 patients with T2D of whom 17 were carriers of rare PPP1R3B variants (Table 3).