When REALITY intervention arms were added one by one to the same model (adjusted for age, sex, baseline hemoglobin level, diastolic blood pressure, PD-1+CD8+ T-cell percentage, and baseline cfPWV), there was no evidence of an association between the week 44 cfPWV and random assignment to enhanced infection prophylaxis (fold change vs standard-prophylaxis, 2%; 95% CI, −9%–11%; P = .76) or to enhanced nutritional support (fold change vs standard support, 8%; 95% CI, −3%–20%; P = .15). The gene discussed is CD8A; the disease is infection.