Consistent with target genes in our lnc-Nr2f1 overexpression study, we found lnc-Nr2f1 KO led to down regulation of neuronal pathfinding and axon guidance genes such as Sema6d and proneural bHLH transcription factor Neurod2 as well as deregulation of genes associated with autism spectrum disorder such as Bdnf, Dcx and Nlgn3 (Basu et al., 2009) (Figure 3G). Here, NLGN3 is linked to autism spectrum disorder.