Moreover, the suppression of tumor volume by EPZ and Thiostrepton was attenuated in the absence of CD8+ T cells, with the CD3+CD8+ T cells were 1,520 ± 18.21, 1,290 ± 10.02, significantly lower than those treated by EPZ or Thiostrepton only as 3,140 ± 34.52, 3,400 ± 15.62 (P < 0.001), respectively. This evidence concerns the gene CD8A and neoplasm.