We found that only the expression of disruptor of telomeric silencing 1‐like (DOT1L), the sole enzyme that specificity mediates H3K79 methylation (Min et al., 2003), correlated with FOXM1 in both pancreatic cancer and colon cancer tissue (Fig. 3B–E and S3A,B). Here, DOT1L is linked to familial pancreatic carcinoma.