In this work, we identified the pro‐tumorigenic function of FOXM1 by inhibiting maturation and antitumor response of bone marrow‐derived dendritic cells (BMDCs) in tumor‐bearing mice (TBM) and mimicking the tumor microenvironment (TME) through FOXM1‐Wnt family number 5A (Wnt5a) signaling. Here, FOXM1 is linked to neoplasm.