Since histone methylation is modified by the histone methyltransferase, we next examined the clinical relevance of histone methyltransferase (MLL1, MLL2, MLL3, MLL4, SET1A, SET1B for H3K4me3 and DOT1L for H3K79me2) and FOXM1 in pancreatic cancer and colon cancer. This evidence concerns the gene SETD1B and familial pancreatic carcinoma.