From a total of 23 KEGG pathways fulfilling these requirements (Fig. 5A), and excluding processes that are rearrangements of core pathways (cancers, other diseases, and Signaling pathways regulating pluripotency of stem cells in the Cellular community superclass), 12 routes remain including 7 signaling pathways (MAPK, Rap1, VEGF, Wnt, TGF‐β, Hippo, and Notch signaling) and 3 related to the endocrine system (Estrogen, Prolactin signaling pathways, and Endocrine and other factor‐regulated calcium reabsorption); see Fig. 5B for a complete list. The gene discussed is PRL; the disease is cancer.