ADORA2A and epilepsy: Thus, A2AR blockade blunted convulsions-induced neurodegeneration while it only attenuated the escalating convulsive profile; this suggests that this prominent neuroprotection might underlie the anti-epileptogenic effect of A2AR antagonists previously reported in other animal models of epilepsy (El Yacoubi et al., 2009; Li et al., 2012).