GNRH1 and pachyonychia congenita: In a recent phase II, randomized, open-label study of NHT with degarelix (gonadotropin-releasing hormone [GnRH] receptor antagonist) versus luteinizing hormone-releasing hormone (LHRH) agonist in patients with PC prior to RP, neoadjuvant degarelix alone was associated with higher levels of intratumoral dihydrotestosterone compared to the use of LHRH agonist and bicalutamide, despite similar testosterone levels [26].