Another randomized phase II trial in patients with intermediate and high risk PC who were administered NHT using LHRH agonists alone versus LHRH agonists plus abiraterone acetate prior to RP found that intraprostatic androgen levels of the prostate specimens were significantly reduced in the abiraterone plus LHRH agonist group than in the LHRH agonist alone group. The gene discussed is GNRH1; the disease is pachyonychia congenita.