HIF1A and colorectal cancer: For example, miR-182 could result in a sustained activation of HIF1α pathway via targeting PHD2 and FIH1 in prostate cancer, which might facilitate tumor cell adaption to hypoxic stress during prostate tumor progression [16]; miR-23b, miR-365-1, and miR-365-2 were identified as biomarkers for colorectal cancer detection by exploring colorectal cancer related miRNA-target gene pairs [17]; overexpression of miR-204 reduced the gastric cancer cell proliferation by targeting CKS1B, CXCL1, and GPRC5A [18].