ALB and neoplasm: The primary site of tumor (HR=0.359, 95%CI=0.174-0.740, P=0.006), the elevated LDH (HR=2.204, 95%CI=1.000-4.858, P=0.050), the reduced ALB (HR=0.459, 95%CI=0.236-0.892, P=0.022), and the elevated LDH combined with elevated SLA (HR=3.187, 95%CI=1.019-9.970, P=0.046) were independent influence factors for OS of mCRC patients (Table 4).