Moreover, Solinas et al. [74] have shown the antiproliferative and anti-invasive effects of CBD in U87-MG cells in a CB1/2 independent manner, and these effects have been extended to T98G glioma cells, a Δ9-THC-resistant lineage, thus suggesting a possible alternative pathway from that involving CB1/CB2 receptors. This evidence concerns the gene CNR1 and central nervous system cancer.