In this study, we found that miR-29a-3p was positively correlated with XPD expression, and suppressed cell proliferation and migration of HCC cell lines, which in line with other works [16], moreover, the ability of miR-29a-3p to suppress cell proliferation and migration was markedly compromised when XPD expression was inhibited. Here, ERCC2 is linked to hepatocellular carcinoma.