To investigate the effects of XPD and miR-29a-3p on tumorigenesis in vivo, SMMC7721 cells transfected with lentiviral vector of XPD overexpression, miR-29a-3p antagomiR, XPD overexpression + miR-29a-3p antagomiR or vehicle were injected subcutaneously into nude mice to initiate tumor formation. This evidence concerns the gene ERCC2 and neoplasm.