Importantly, a significant number of the mutations were detected solely in the metastatic SS (Table 1 and Supplementary Table 1), which include the missense mutations in ADAM17, ADAM17-P729H (nt: C2186A) and ADAM17-K805T (nt: A2414C) detected in Samples SARC5001 and SARC5003, respectively (Table 1 and Supplementary Table 1). The gene discussed is ADAM17; the disease is synovial sarcoma.