Although downregulation/mutation of LIG4 (and its partner XRCC4) was detected only in approximately 4% of glioblastomas in The Cancer Genome Atlas (TCGA) database [26] inhibition/inactivating mutation of other members of D-NHEJ potentially impairing DSB repair activity were present in up to 20% of the cases. This evidence concerns the gene XRCC4 and glioblastoma.