TXNIP and hepatocellular carcinoma: On the other hand, when control SNU-449 cells were injected into yolk sac, 75% of the xenografts displayed metastatic behavior (Figure 5C, right panel) and this was significantly reduced to 32% when TXNIP was silenced with siRNA in SNU-449 cells (Figure 5C, right) Collectively, our data suggest that TXNIP is a potent inducer of metastasis in HCC cells in vivo.