To this end, works carried out in the hippocampus demonstrate that TNFα regulate the development of the hippocampus, as TNF-R1 and TNF-R2 knockout mice demonstrate decreased arborization of the apical dendrites of the CA1 and CA3 regions and accelerated dentate gyrus development [51], and altered regions in schizophrenia as well. The gene discussed is TNFRSF1B; the disease is schizophrenia.