TNF and immune system disorder: As for TNFβ which has an immunomodulator function [23, 30] and carries a predisposition to various immune diseases that frequently accompany mood disturbance [36, 37], TNFB∗G of the first intron TNFB +252A/G polymorphism seems also to be associated with high TNFα and TNFβproduction [23, 38].