In the current study, a significant increase was observed in the mean serum Apo A1 level of post-intervention compared with pre-intervention in the aerobic exercise group and the significant changes in the aerobic exercise group compared with the control group showed that regular aerobic exercises can play an effective role in improving the respiratory efficacy in patients with COPD through an increase in the serum levels of ApoA1. The gene discussed is APOA1; the disease is chronic obstructive pulmonary disease.