Compared with the db/db misty mice, these diabetic db/db mice exhibited the classical features of the mouse T2D model, such as severe hyperglycemia (HbA1c, 8.3 ± 0.2% vs. 4.2 ± 0.1%; FBG, 432 ± 26 mg/dL vs. 107 ± 5 mg/dL), hyperphagia (food intake, 4.5 ± 0.2 g/day vs. 3.1 ± 0.1 g/day), high body weight gain (43.8 ± 0.6 g vs. 25.4 ± 0.3 g), high insulin concentration (2.48 ± 0.32 ng/dL vs. 0.27 ± 0.03 ng/dL), and high triglyceride levels (134 ± 16 mg/dL vs. 91 ± 3 mg/dL). The gene discussed is INS; the disease is type 2 diabetes mellitus.