The combination of anti-VEGFR2 antibodies with PD-L1 antibodies induced formation of HEVs and improved T-cell infiltration in the polyoma middle T oncoprotein (PyMT) breast cancer model and the Rip1-Tag2 pancreatic neuroendocrine tumor model (RT2-PNET) (86). This evidence concerns the gene CD274 and breast carcinoma.