IL12RB1 and fungal infectious disease: In a study published in 2014, Candida infections (mainly oropharyngeal) were found in 43 of 151 (28%) patients with mutations in the IL12RB1 gene (27), and the fungal infection was recurrent or persistent in 74% of those patients despite oral or intravenous antifungal treatments (mainly with nystatin or fluconazole).