Additionally, for some autosomal recessive forms of HSP such as SPG11, SPG15, and SPG48, which are characterized by dysfunction in autophagy and endolysosomal pathways, compounds that induce autophagy have been suggested as treatment, such as carbamazepine, rapamycin, among others (12). The gene discussed is ZFYVE26; the disease is hereditary spastic paraplegia.