In particular, RAPGEF1 with the intronic SNP rs11243444 (Hong et al., 2009) and PIK3C2G with the two intronic SNPs rs10841048 and rs12816270 (Daimon et al., 2008) reported association with DM Non-Insulin Dependent, PPARGC1A has the upstream SNP rs590183 associated with blood pressure (O'donnell et al., 2007) and ANGPTL8 shows the missense variant rs2278426 associated with high density lipoprotein measurement (Weissglas-Volkov et al., 2013). The gene discussed is RAPGEF1; the disease is diabetes mellitus.