TF and autoimmune polyendocrinopathy: Conversely, the exposure of endothelial cells to aPL upregulates endothelial expression of monocyte chemoattractant protein 1 (MCP-1), which in turn promotes TF synthesis by monocytes (Figure 1A) (Cho et al., 2002), leading to thrombotic complications in patients with primary APS (Cuadrado et al., 1997).