TAC3 and mood disorder: Alhadeff et al. (2018) have now shown that, of these three molecules, NPY via its NPY Y1 receptor is selectively responsible for a pain-inhibiting effect. Finally, based on a Drosophila study (Asahina et al., 2014), Zelikowsky et al. (2018) use a battery of the most recent methodologies to conduct a landmark study that demonstrates a key role for the neuropeptide tachykinin 2/neurokinin B and its receptor NK3 in chronic isolation stress, opening up for a new treatment strategy of this serious mood disorder.