A candidate gene study of a cohort of European White ethnic origin totaling 2,361 from Manchester, United Kingdom and Budapest, Hungary was carried out (Juhasz et al., 2014) and revealed that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity and/or recent negative life events (Figure 9). Here, GAL is linked to depressive symptom measurement.