Shank2 Δe7–/– mice (Schmeisser et al., 2012) display extreme hyperactivity and profound autism-like behavior, such as repetitive grooming and abnormalities in vocal and social behaviors, accompanied by reduced basal synaptic transmission, decreased frequency of mEPSCs and an increased NMDA/AMPA ratio consistent with increased levels of the NMDAR subunit GluN1 in the hippocampus and striatum. The gene discussed is SHANK2; the disease is autism.