ABCA7 and Alzheimer disease: Additionally, elevated LPCs have been related to pathological lipid breakdown and the state of parenchymal inflammation after ischemia as an important source of reactive oxygen species (ROS) (Adibhatla and Hatcher, 2007; Wang et al., 2010), as well as being correlated with macrophage/microglia responses and neuronal death (Nielsen et al., 2016), spatial memory dysfunction (Köfeler et al., 2010) and its efflux and transport by ABCA7 in dementia by AD (Tomioka et al., 2017), also serving as a strategy in the forecast of ischemic stroke (Jickling and Montaner, 2015).