ANXA5 and breast adenocarcinoma: Our results also demonstrate that, this increase in Annexin-V can be measured in tumor in vivo in a preclinical model of breast adenocarcinoma with radiolabelled 99mTc-HYNIC-Annexin V. This tool could represent a reliable way to monitor early apoptosis induced by anticancer agents in order to evaluate early treatment efficacy and allow improvement of therapeutic strategies.