Hence, in the current study, we identified a 6-mRNA panel signature (ART5, FOXD1, HIST3H2BB, TIMP1, EPHA6 and IRX6) for CRC after the univariate and multivariate Cox proportional hazards regression analysis on the mRNA expression profile from the CRC, COAD, and READ patients on the basis of the data collected from the TCGA database. Here, EPHA6 is linked to colon adenocarcinoma.