Hence, in the current study, we identified a 6-mRNA panel signature (ART5, FOXD1, HIST3H2BB, TIMP1, EPHA6 and IRX6) for CRC after the univariate and multivariate Cox proportional hazards regression analysis on the mRNA expression profile from the CRC, COAD, and READ patients on the basis of the data collected from the TCGA database. This evidence concerns the gene H2BC26 and colorectal carcinoma.