BAG5 and depressive symptom measurement: In the bivariate GWAS with self-reported MDD, we reported one novel genetic locus mapping to MUC21. The bivariate GWAS with schizophrenia yielded 16 loci (listed in Table 1), 10 of which replicated, including 7 novel for depression: ZNF804A, MIR3143, PSORS1C2, STK19, SPATA31D1, RTN1 and TCF4. Out of the five previously reported loci, NEGR1 and MAT2B were previously reported as associated with self-reported MDD [5], FHIT with broad depression [6], ITIH3 was detected in a cross-disorder GWAS [15] and finally BAG5 was identified in the recent PGC meta-GWAS for MDD [9].