LDHA and neoplasm: However, the data demonstrate instead that while in vivo deletion of Ldha did affect the metabolism of the tumors formed, this did not affect cancer cell proliferation, survival, pathology, immune response etc. Perhaps in vitro data showing that Ldh inhibition can block tumor growth are incomplete because tumor cells in vivo can take up lactate from the blood to make up for the loss of Ldh activity in the treated cells.