These responses were not specific to KBM-7 cells, as increased TNFα sensitivity was also observed in a dose-dependent manner upon BRCA2 depletion in a panel of TNBC cell lines (Fig. 4c, Supplementary Fig.4a, 5b) and in the colorectal cancer cell line DLD-1, in which the BRCA2 gene was inactivated using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated 9) (Fig. 4d, Supplementary Fig. 5c). The gene discussed is TNF; the disease is colorectal cancer.