This provides some explanation for the past failures of translating promising therapeutics from SOD1 transgenics to ALS patients, 98% of whom do not suffer from SOD1-ALS (Urushitani et al., 2007; Turner and Talbot, 2008; Riboldi et al., 2011; Vallarola et al., 2018). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.