Other well known ‘ALS genes’ include TAR DNA-binding protein (TARDBP; encoding TDP-43), found in ∼5% of fALS and ∼2% of sALS, and fused in sarcoma (also known as FUS RNA-binding protein; FUS), found in ∼6% of fALS and ∼1% of sALS (Ingre et al., 2015; Tarlarini et al., 2015). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.