TARDBP and amyotrophic lateral sclerosis: This mutant TDP-43 GOF affects the splicing of a subset of genes not previously known to be controlled by TDP-43, leading to the appearance of new exon exclusion events called ‘skiptic exons’ that are, at least partially, also present in human TDP-43-ALS fibroblast cells (Fratta et al., 2018) (Table 1b).