This enhanced glucose oxidation was accompanied by an activation of PDH (the rate-limiting enzymes for glucose oxidation) and the IRS-1/Akt/GSK-3β signalling pathway, a major component of the reperfusion injury salvage kinase (RISK) pathway, which is a cardioprotective signalling pathway post-MI [52]. This evidence concerns the gene AKT1 and myocardial infarction.