Increases in blood NfL have also been described in frontotemporal dementia (Rohrer et al. 2016), Huntington’s disease (Byrne et al. 2017) and atypical parkinsonian disorders (Hansson et al. 2017), making blood NfL a global marker of neurodegeneration rather than a disease-specific biomarker per se. Here, NEFL is linked to frontotemporal dementia.