HLA-C and neoplasm: Interestingly, avidity to recognize titrated peptides was comparable in CD8+ T cells when they were engineered to express TCRs from 19305DP and conventional CD8+ T cells (CD8SP), indicating that CD8-MHC interaction and/or CD8-signaling could sufficiently compensate lower affinity by tumor antigen-specific conventional CD8+ T cells (Fig. 3b).