Among the seven CAFs that were shown to be significantly related to MM response to therapy (Fig. 2), low (relative to median) concentrations of ANG-2 (p < 0.0001), FGF-2 (p < 0.0001), HGF (p < 0.0001), IL-8 (p < 0.0001), PDGF-BB (p < 0.0001), TNF-α (p < 0.001), and VEGF (p < 0.0001) highly correlated with best response (Additional file 1: Table S2). Here, HGF is linked to Miyoshi myopathy.