TNF and cancer: We evaluated the concentration of ANG-2, FGF-2, HGF, IL-8, PDGF-BB, TIMP-1, TIMP-2, TNF-α, and VEGF that are the major cytokines involved in angiogenesis in MM and other cancers [36] and, as previously demonstrated [37] in MM patients, directly correlate with disease activity and increase with progression.