To develop our gene signature uniting hypoxia and tumor-infiltrating T-cells, we utilized three gene sets: (1) pan-cancer hypoxia genes (52 genes) [6]; (2) HCC-infiltrating Tregs (401 genes) and (3) HCC-infiltrating exhausted CD8+ T cells (82 genes) [8] (Fig. 1). The gene discussed is CD8A; the disease is cancer.