BiKEs and TriKEs are small molecules (50–75 kDa compared to 300–450 kDa of bi- and tri-specific antibodies [162]) encoded by a single-chain variable fragment (scFv) comprised of a variable heavy and variable light chain (VH and VL) against CD16 linked to the scFv of either one (BiKEs) or two (TriKEs) variable regions from other Abs that target tumour antigens. This evidence concerns the gene FCGR3A and neoplasm.