NKG2D-CARs can bestow T cells with cytotoxic and cytokine secreting functions against tumour cell targets and control the growth of a number of tumour types in mouse models of multiple myeloma [155], ovarian carcinoma [156], osteosarcoma [157], breast cancer [158], and glioblastoma [159], and have also been adopted to enhance the activity of NK cells in osteosarcoma [160]. This evidence concerns the gene KLRK1 and osteosarcoma.