Of note, [17] showed that similarly, transplantation of a genetically obese human microbiota (Prader-Willi syndrome (PWS)) to GF mice produced larger adipocytes and a higher inflammatory response (increased liver, colonic and ileum TNF-α, TLR4 and IL6 gene expression, respectively) than did GF mice administered a post-intervention transplantation. The gene discussed is TLR4; the disease is Prader-Willi syndrome.