PGP and uterine corpus sarcoma: One study reported that a radio-iodinated piperazine derivative, 5-[3-{4-(2-phenyl-2-(4-[125I]iodo-phenyl)acetyl)piperazin-1-yl}-2-hydroxypropoxy] quinoline, induced approximately a 10-fold shorter absorption half-life and a 50% shorter mean residence time in xenograft mice inoculated with P-gp overexpressed in human uterine sarcoma cells (MES-SA/Dx5) than those in the parental cells [24].