The cyclic dipeptide with documented anti-inflammatory and anti-cancer activity that is naturally produced by bacteria, fungi, marine sponges, gorgonian and red algae has been reported to inhibit tumor necrosis factor (TNF)-α, and interleukin (IL)-1β-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs) [99]. The gene discussed is TNF; the disease is cancer.