IFNAR1 and Zika virus infectious disease: The role of type IFN I during pregnancy in infected mothers have been assessed using IFNAR(−/−) mice [103], and the findings highlight the detrimental impact of type I IFN on the developing placenta and fetus by demonstrating that only the fetuses with a functional copy of IFNAR are resorbed after ZIKV infection, whereas their IFNAR(−/−) littermates continue to develop, even having higher ZIKV titers in their placentas.