They were able to trigger strong humoral and cellular immune responses comparable with those achieved in the immunocompetent model, as it has been shown in this review for RVFV, CCHFV, DENV, ZIKV, CHICK, BTV or AHSV, where high levels of neutralizing antibodies that block the virions or cytotoxic CD8 T cell responses, able to clear the infection, were induced using different platforms (inactivated vaccines, attenuated-replication defective, subunit vaccines, DNA or viral vector based vaccines) and vaccination strategies (single dose, prime-boost). The gene discussed is CD8A; the disease is infection.