CD8A and infection: The recruitment of cytotoxic cells to the site of infection mediated by chemokine production has been shown, as well as the induction of cytokines from CTLs that positively regulate cytotoxic cell populations and activities, as interleukin (IL)-15 type I IFN-induced production, which plays a critical role in proliferation and maintenance of NK cells and memory CD8+ T cells [19].