Using the IFNAR(−/−) mice model, it has been possible to determine how THOV infection of mice leads to an unexpected strong and long-lasting mode of type I IFN expression that is most likely dominated by IPS-1-dependent IFN production of infected myeloid dendritic cells (mDC), but not plasmacytoid pDC cells [64]. Here, IFNA1 is linked to infection.