For instance, severe fever with thrombocytopenia syndrome virus (SFTSV) (with case fatality rates up to 30% in humans), Bunyamwera virus (BUNV), Dugbe virus (DUBV), and the Simbu virus (SIMV) [43,78,79,80,81], where the effect of the host IFN system and IFN-related genes on the outcome of infection, model suitability, and vaccination have been investigated in IFNAR(−/−) mice. The gene discussed is IFNAR1; the disease is infection.