TNF and Cognitive impairment: The first and most logic approach is the use of immunosuppressant drugs, since inflammation is the first link in the neuroimmune-cascade resulting in fatigue, cognitive impairment, and depressive symptoms (e.g., anhedonia), In agreement, TNF-α antibodies (e.g., infliximab) improve sleep quality [86] and depressive symptoms in patients with high baseline inflammatory biomarkers [87].