TRPM2 and Parkinson disease: For example, in addition to the revelation of a role for the TRPM2 channel in mediating MPP-induced SH-SY5Y cell death, the recent study by Sun et al. [23] has found strong up-regulation of the TRPM2 expression in MPP-treated SH-SY5Y cells as observed in the substantia nigra pars compacta (SNpc) of the brains from PD patients and PD mice induced by injection with 1-methyl-4-phenyl-tetrahydropyridine to selectively destroy dopaminergic neurons in the SNpc region.