As already introduced above, in addition to the revelation of the importance of the TRPM2 channel in mediating MPP-induced SH-SY5Y cell death, Sun et al. have shown strong up-regulation of the TRPM2 expression in MPP-treated SH-SY5Y cells as observed in the SNpc region of the brains from PD patients and also PD mice [23]. Here, TRPM2 is linked to Parkinson disease.