The stability of the occludin protein in the OE-TLR3(-) cells was mostly unaffected by the Chlamydia infection as it was in the OE-129WT cells, and pre-treating the OE-TLR3(-) cells with IFN-β prior to infection had only a minor impact on the stability and expression levels of both occludin and ZO-1. The gene discussed is IFNB1; the disease is chlamydia infectious disease.