Pretreatment of TLR3-deficient OE cells with 50U/ml exogenous IFN-β for 1hr before infection resulted in a significant reduction chlamydial progeny; however, pre-treatment with exogenous IFN-β had no significant impact on C. muridarum infection and replication in wild-type OE cells [8]. This evidence concerns the gene IFNB1 and infection.