TNF and psychiatric disorder: Statins are anti-inflammatory, with effects on levels of interleukin-1β, interleukin-6, tumor necrosis factor, and C-reactive protein.18,19 Extensive evidence suggests that systemic and neuroinflammatory processes are involved in the pathophysiology of psychiatric disorders.4 Alternatively (or synergistically), HMG-CoA RIs may interact with other substrates for P-glycoprotein (including antipsychotic medications).