In contrast, the mechanism for treatment of hypercholesterolemia is slower, involving inhibition of HMG-CoA reductase, a resultant reduction in hepatocyte cholesterol level, and an increase of hepatic low-density lipoprotein receptor levels, which clear circulating low-density lipoprotein and its precursors.24 The gene discussed is VLDLR; the disease is Hypercholesterolemia.