POMC and hypopituitarism: During this period, two cases of pan-hypopituitarism (normal ACTH, adrenocorticotropic hormone), two with genetically confirmed Pit-1 defect (deficiency of TSH, growth hormone, and prolactin), and one with isolated TSH deficiency (Figure 2) were also diagnosed independent of the screening program and were included in the overall prevalence without performing TS.