The most common marker used in clinical practice to identify AKI is the serumcreatinine level.(4,5) Despite its widespread dissemination, researchershave indicated that slight elevations of serum creatinine may result in severeoutcomes, which suggests it is not efficient as an early marker, but rather a latemarker for kidney dysfunction.(6) The discovery of new markers, such as NeutrophilGelatinase Associated Lipocalin, Kidney Injury Molecule-1 and Interleukin-18, havebroadened the horizons in the identification of AKI in its early stage. The gene discussed is IL18; the disease is acute kidney injury.