ABCB8 and melanoma: Mitoferrin-1 and mitoferrin-2 mediate iron uptake in fibroblasts, murine embryonic stem cells, and erythroleukemia cells (Chen et al., 2010, Paradkar et al., 2009), whereas recent evidence shows that the mitochondrial inner membrane transporter ABCB8 regulates ionic iron export and protects mitochondria from iron overload in melanoma cells and cardiomyocytes (Ardehali et al., 2005, Ichikawa et al., 2012, Ichikawa et al., 2014).