The other study reported that epithelial IL1R2 acted as a homeostatic regulator during remission of ulcerative colitis (Mora‐Buch et al., 2016), and another suggested that IL1R2 was an important regulator of arthritis by acting specifically on macrophages as a decoy receptor for IL‐1 (Shimizu et al., 2015). Here, IL1B is linked to Arthritis.