Another study involving the association between five SNPs polymorphisms in IL1R1 (rs10490571, rs12712127, rs956730, rs3917225, and rs3917318) and osteoarthritis risk, the result found that rs3917225 in IL1R1 was associated with increasing the risk of knee OA (Na et al., 2017; Smith et al., 2004). The gene discussed is IL1R1; the disease is osteoarthritis.